Characterisation of New Elovl family from zebrafish

by Shouxiang Sun; Yumei Wang; Pei-Tian Goh; Mónica Lopes-Marques; L. Filipe C. Castro; Óscar Monroig; Meng-Kiat Kuah; Xiaojuan Cao; Alexander Chong Shu-Chien; Jian Gao

Multi-cellular organisms rely on several Elovl elongase to convert polyunsaturated fatty acids (PUFA) such as linolenic acid (C18:3n-3) to the all-important EPA and subsequently, DHA.  Depending on species, the Elovl5, Elovl2 and Elovl4 are the 3 families known to have PUFA-elongation capacities that contribute to the LC-PUFA biosynthesis pathway.  This present work involving researches from Spain, Portugal and China proposed that a new Elovl family, the Elovl8 also possessed a similar elongation capacity.  Using the versatility of zebrafish-related tools, these researchers showed the capacity of saturated fatty acid and PUFA in two Elovl9 isoforms.

  

Link :  https://www.mdpi.com/2073-4425/12/8/1287

CCB Ref.:  2021_RH_1_alex
Date :  30/11/2021