Research - Chemical Biology

{slider-nested What It Is About}

Chemical biology combines the scientific thoughts and advances of chemistry, biology and allied disciplines to understand and manipulate biological systems with molecular precision. Many of the present day biological problems demand molecular and quantitative solutions that can be supplied by tools and approaches derived from chemistry that target various systems of interest such as proteomics, synthetic biology, employing biology, molecular sensing, and glycobiology among others.

Researchers in our group currently focus on two major groups of organism, insects and microbes. Dr. Veera Singham and his team focuses on understanding underlying molecular mechanisms of insecticide resistance in pest insects and also to elucidate chemicals that regulate or influence behaviours or biological responses in insects. Dr. Eng Su Anne scope focuses on the discovery and characterization of novel anti-infectives that target bacterial virulence or alternatively, improve host immunity by utilizing C. elegans – Pseudomonas aeruginosa PA14 model. Our group also made collaborative effort with Prof. Ahmad Sofiman Othman to investigate transcription factors associated to secondary laticifer differentiation in the para rubber tree, Hevea brasiliensis.

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{tab=2020}
Morphological abnormalities in caddisfly larvae (Hydropsyche doctersi) as indicator of water quality in tropical rivers
Ab Hamid, S., Mohd Afandi, M.F.S., Ganesan, V.S.A.L.K., Hashim, N.A., Al-Shami, S.A.,
(2020) Journal of Entomolgy Research, 44 (2), pp. 267-276

Infestation Pattern and Population Dynamics of theInfestation Pattern and Population Dynamics of theTropical Bed Bug, Cimex hemipterus (F.) (Hemiptera:Cimicidae) Based on Novel Microsatellites andmtDNA Markers
Wan Nur Fatanah Wan Mohammad, Li-Shen Soh, Wan Nurainie Wan Ismail, G. Veera Singham
(2020) Mitochondrial DNA Part B: Resources, 5 (3), pp. 2024-2025.

Performance of commercial insecticide formulations against different developmental stages of insecticide-resistant tropical bed bugs (Hemiptera: Cimicidae)
Leong, X.-Y., Kim, D.-Y., Dang, K., Singham, G.V., Doggett, S.L., Lee, C.-Y.
(2020) Journal of Economic Entomology, 113 (1), pp. 353-366.

{tab=2019}
Circadian rhythms in insecticide susceptibility, metabolic enzyme activity, and gene expression in Cimex lectularius (Hemiptera: Cimicidae)Cimex lectularius (Hemiptera: Cimicidae)
Khalid, M.F., Lee, C.-Y., Doggett, S.L., Veera Singham, G.
(2019) PLoS ONE, 14 (6), art. no. e0218343, .

Identification and characterization of jasmonic acid- and linolenic acid-mediated transcriptional regulation of secondary laticifer differentiation in Hevea brasiliensis
Loh, S.C., Othman, A.S., Veera Singham, G.
(2019) Scientific Reports, 9 (1), art. no. 14296,

Single-nucleotide polymorphism markers within MVA and MEP pathways among Hevea brasiliensis clones through transcriptomic analysis
Abdul Rahman, S.N., Bakar, M.F.A., Singham, G.V., Othman, A.S.
(2019) 3 Biotech, 9 (11), art. no. 388,

{tab=2018}
Morphometric variation and genetic relationship of coptotermes spp. (Blattodea: Rhinotermitidae) in Sarawak, Malaysia
Jamil, N., Wan Ismail, W.N., Singham, G.V.
(2018) Malaysian Applied Biology, 47 (6), pp. 113-125.

{tab=2017}
Phylogeography of the termite Macrotermes gilvus and insight into ancient dispersal corridors in Pleistocene Southeast Asia
G. Veera Singham, Ahmad Sofiman Othman, Chow-Yang Lee.
(2017), PLOS One, doi.org/10.1371/journal.pone.0186690

Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)
Dang, K., Doggett, S.L., Veera Singham, G., Lee, C.-Y.
(2017), Parasites and Vectors, doi:10.1186/s13071-017-2232-3

Effects of Different Surfaces and Insecticide Carriers on Residual Insecticide Bioassays Againts Bed Bugs, Cimex spp. (Hemiptera: Cimicidae)

Kai Dang, G. Veera Singham, Stephen L. Doggett, David G. Lilly and Chow-Yang Lee.
(2017), Journal of Economic Entomology, 1-9

Large-scale collection of full-length cDNA and transcriptome analysis in Hevea brasiliensis
Yuko Makita, Kiaw Kiaw Ng, G. Veera Singham, Mika Kawashima, Hideki Hirakawa, Shushei Sato, Ahmad Sofiman Othman, Minami Matsui.
(2017), DNA Research, 1-11

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Dr. Veera Singham A/L K Genasan (Lecturer)

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Research - Chemical Biology

Performance of commercial insecticide formulations against different developmental stages of insecticide-resistant tropical bed bugs (Hemiptera: Cimicidae)Leong, X.-Y., Kim, D.-Y., Dang, K., Singham, G.V., Doggett, S.L., Lee, C.-Y.(2020) Journal of Economic Entomology, 113 (1), pp. 353-366.

{tab=2019}Circadian rhythms in insecticide susceptibility, metabolic enzyme activity, and gene expression in Cimex lectularius (Hemiptera: Cimicidae)Cimex lectularius (Hemiptera: Cimicidae)Khalid, M.F., Lee, C.-Y., Doggett, S.L., Veera Singham, G.(2019) PLoS ONE, 14 (6), art. no. e0218343, .

Identification and characterization of jasmonic acid- and linolenic acid-mediated transcriptional regulation of secondary laticifer differentiation in Hevea brasiliensisLoh, S.C., Othman, A.S., Veera Singham, G.(2019) Scientific Reports, 9 (1), art. no. 14296,

Single-nucleotide polymorphism markers within MVA and MEP pathways among Hevea brasiliensis clones through transcriptomic analysisAbdul Rahman, S.N., Bakar, M.F.A., Singham, G.V., Othman, A.S.(2019) 3 Biotech, 9 (11), art. no. 388,

{tab=2018}Morphometric variation and genetic relationship of coptotermes spp. (Blattodea: Rhinotermitidae) in Sarawak, MalaysiaJamil, N., Wan Ismail, W.N., Singham, G.V.(2018) Malaysian Applied Biology, 47 (6), pp. 113-125.

{tab=2017}Phylogeography of the termite Macrotermes gilvus and insight into ancient dispersal corridors in Pleistocene Southeast AsiaG. Veera Singham, Ahmad Sofiman Othman, Chow-Yang Lee.(2017), PLOS One, doi.org/10.1371/journal.pone.0186690

Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)Dang, K., Doggett, S.L., Veera Singham, G., Lee, C.-Y.(2017), Parasites and Vectors, doi:10.1186/s13071-017-2232-3