P(3HB-co-4HB) as high value polyhydroxyalkanoate: its development over recent decades and current advances

by Kai-Hee Huong, Vigneswari Sevakumaran & A. A. Amirul

Polyhydroxyalkanoate (PHA) is among the emerging biopolymers that has gained much attention as the next generation biobased and biodegradable thermoplastics since it is an excellent substitute for petroleum-based synthetic plastics. Among all the PHAs discovered, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] stands out as a next-generation healthcare biomaterial for having high biopharmaceutical and medical value since it is highly compatible with mammalian tissue. This review provides a critical assessment and complete overview of the development and trend of P(3HB-co-4HB) research over the last few decades, highlighting aspects from microbial strain discovery to metabolic engineering and bioprocess cultivation strategies. The article also outlines the relevance of P(3HB-co-4HB) as a material for high value-added products in numerous healthcare-related applications.



Figure 1 of 1 
Figure 1. (A) Chronological order of wild type microorganisms discovered to produce P(3HB-co-4HB) [It is noteworthy that the designated year was not based on the bacterial isolated/sampling date. For instance, C. necator H16, KCTC 2662 (H20) and DSM545 (H 1 G+3) were discovered before 1975 but revealed to produce P(3HB-co-4HB) at 1988, 2011 and 2012 respectively]; (B) The succinate degradation pathway and its relevance as metabolic engineering approach for P(3HB-co-4HB)/P(4HB) production in E. coli; (C) Comprehensive view on up-to-date reported strategies for the production/enhancement of P(3HB-co-4HB)/P(4HB) via bioprocess engineering and metabolic engineering approach.


Link :  https://www.tandfonline.com/doi/full/10.1080/07388551.2020.1869685



CCB Ref.:  2021_RH_3_azura
Date :  01/12/2021